Mandible metastasis of small cell lung cancer mimicking a residual cyst

Small cell lung carcinoma (SCLC) is an uncommon tumor characterized by an aggressive behavior with early metastasis, usually to the contralateral lung, liver, brain, and bones. There are only five cases of this particular tumor metastasizing to the oral cavity described in the English literature. We present the case of metastatic SCLC in the mandible with radiographic findings resembling a residual cyst. A 66-year-old man with previous diagnosis and treatment for a SCLC was referred to the Stomatology Department with a history of persistent pain in the mandible 1 year after the inferior right pre-molar tooth extraction. The radiographic exam showed a well-delimited radiolucent area on that extracted tooth's region resembling a residual cyst. Biopsy was performed yielding the diagnosis of metastatic SCLC. The patient was referred to the clinical oncologist for chemotherapy. Although uncommon, this tumor should be included in the differential diagnosis of jawbone lesions, particularly when the patient presents a previous diagnosis of SCLC.

Small cell carcinoma of the urinary bladder: virtual CT cystoscopic findings.

A 74-year-old man underwent multidetector CT virtual cystoscopy due to macroscopic hematuria. A large, irregularly-surfaced, solid bladder mass was detected, infiltrating the perivesical fat, the seminal vesicles and the prostate. CT examination of the chest and abdomen showed no distant metastases. Radical cystectomy was performed and pathology reported pure small cell carcinoma of the urinary bladder.

study of paraneoplastic syndrome patterns in patients with bronchogenic carcinoma

Paraneoplastic syndromes, which are the distant effect of underlying carcinoma, which can present early, well before the primary lung lesion produces local symptoms and even when the tumor is undetected or very small. Paraneoplastic syndromes are common in patients with bronchogenic carcinoma. They may be the presenting finding or the first sign of recurrence. To assess the incidence and pattern of paraneoplastic syndrome [PNS] in patients with bronchogenic carcinoma. Peripheral Hospital in Kuwait. Retrospective study. A retrospective study of 52 confirmed bronchogenic carcinoma patients occurring from January 2000 to June 2004 in our hospital was carried out. The Medical records of all the confirmed cases of bronchogenic carcinoma admitted between January 2000 and June 2004 were reviewed. The clinical and biochemical parameters recorded were: age, sex, underlying medical illness, presentation complete blood count, blood urea, electrolytes and serum calcium levels, and appropriate hormone levels where indicated. The localization of the tumors was done by chest x-ray and CT scan. Tissue biopsy was obtained by bronchoscopy or under CT scan guidance and histopathological examination of the specimen was carried out. The type and pattern of PNS if any was noted. These parameters were entered into a database and later analyzed. The data management and statistical package used was Epi Info version 6 provided readily by the CDC [Centre for Disease Control] Bethesda USA. Forty-nine patients were male and 3 were females. All were heavy smokers or exsmokers. The histological types were 12 [22.4%] small cell carcinoma and 40 [67.6%] nonsmall carcinoma. The mean age 67.46 +/- 12.15 years. Associated illness found was diabetes mellitus [DM] ' 24 [46%], hypertension - 33 [63.6%], and chronic obstructive pulmonary disease [COPD] - 14 [27%]. Almost all the patients presented with cough - 52 [100%], shortness of breath [SOB] - 51 [99%], haemoptysis - 22 [42%], pleural pain - 16 [31%] and fever - 22 [42%] and weight loss - 39 [75%]. The PNS found were: Hypercalcemia - 22 [42%], thrombocytosis - 5 [9.6%], limbic encephalitis - 3 [5.8%], SIADH - 3 [5.8%], peripheral neuropathy - 2 [3.8%], GBS - 1 [1.9%], pancytopenia - 3 [5.8%]. There was no case with ACTH secretion or Lambert-Eaton syndrome. Hypercalcemia, thrombocytosis, SIADH, pancytopenia, limbic encephalitis and other unexplained neurological problems occurring in the middle aged or elderly smokers should arouse the suspicion of an occult bronchogenic carcinoma

Metastasis-induced acute pancreatitis in a patient with small cell carcinoma of the lung

Acute pancreatitis in cancer patients can be secondary to the malignant process itself or a complication of antineoplastic agent administration. However, acute pancreatitis caused by metastatic carcinoma of the pancreas is an uncommon condition with a poor prognosis. We report a case of a 63-year-old man with small cell carcinoma of the lung, who developed acute pancreatitis lately. Thirteen months earlier, he developed small cell carcinoma of the lung and received 6 cycles of chemotherapy. Abdominal CT scan showed swelling of the pancreas with multiple masses. The patient was managed conservatively and pancreatitis subsided. This case indicates that metastasis induced acute pancreatitis can be a manifestation of lung cancer, especially in small cell carcinoma.